Differential recognition of microfilarial antigens by sera from immigrants into an area endemic for brugian filariasis.
Identifieur interne : 00DA36 ( Main/Exploration ); précédent : 00DA35; suivant : 00DA37Differential recognition of microfilarial antigens by sera from immigrants into an area endemic for brugian filariasis.
Auteurs : L. Kurniawan [Indonésie] ; E. Basundari ; J A Fuhrman ; H. Turner ; H. Purtoma ; W F PiessensSource :
- Parasite immunology [ 0141-9838 ] ; 1990.
Descripteurs français
- KwdFr :
- Adulte, Animaux, Anticorps antihelminthe (analyse), Anticorps antihelminthe (immunologie), Anticorps monoclonaux (immunologie), Antigènes d'helminthe (analyse), Antigènes d'helminthe (immunologie), Brugia (immunologie), Femelle, Filariose lymphatique (immunologie), Filariose lymphatique (épidémiologie), Filarioses (immunologie), Fixation compétitive, Humains, Immunoglobuline G (analyse), Immunoglobuline G (immunologie), Immunoglobuline M (analyse), Immunoglobuline M (immunologie), Immunotransfert, Indonésie, Mâle, Technique de Western, Test ELISA.
- MESH :
- analyse : Anticorps antihelminthe, Antigènes d'helminthe, Immunoglobuline G, Immunoglobuline M.
- immunologie : Anticorps antihelminthe, Anticorps monoclonaux, Antigènes d'helminthe, Brugia, Filariose lymphatique, Filarioses, Immunoglobuline G, Immunoglobuline M.
- épidémiologie : Filariose lymphatique.
- Adulte, Animaux, Femelle, Fixation compétitive, Humains, Immunotransfert, Indonésie, Mâle, Technique de Western, Test ELISA.
- Wicri :
- geographic : Indonésie.
English descriptors
- KwdEn :
- Adult, Animals, Antibodies, Helminth (analysis), Antibodies, Helminth (immunology), Antibodies, Monoclonal (immunology), Antigens, Helminth (analysis), Antigens, Helminth (immunology), Binding, Competitive, Blotting, Western, Brugia (immunology), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (immunology), Enzyme-Linked Immunosorbent Assay, Female, Filariasis (immunology), Humans, Immunoblotting, Immunoglobulin G (analysis), Immunoglobulin G (immunology), Immunoglobulin M (analysis), Immunoglobulin M (immunology), Indonesia, Male.
- MESH :
- chemical , analysis : Antibodies, Helminth, Antigens, Helminth, Immunoglobulin G, Immunoglobulin M.
- chemical , immunology : Antibodies, Helminth, Antibodies, Monoclonal, Antigens, Helminth, Immunoglobulin G, Immunoglobulin M.
- geographic : Indonesia.
- epidemiology : Elephantiasis, Filarial.
- immunology : Brugia, Elephantiasis, Filarial, Filariasis.
- Adult, Animals, Binding, Competitive, Blotting, Western, Enzyme-Linked Immunosorbent Assay, Female, Humans, Immunoblotting, Male.
Abstract
Studies in animal models indicate that antibodies to surface antigens of microfilariae participate in the control of parasitaemia resulting from infections with lymphatic filarial nematodes. In an attempt to identify parasite antigens that elicit such 'protective' host responses, we compared the antigen recognition patterns of persons who remained amicrofilaraemic after 3-6 years of exposure to Brugia malayi with those of individuals who developed patent filariasis during the same period. IgG antibodies in sera from immigrants identified between 0 and 25 microfilarial antigens on Western blots. The highest degree of reactivity was observed with antigens in the 65-75 kD and 20-30 kD ranges, and with a group of high mol. wt antigens (greater than 180 kD). Sera from amicrofilaraemic donors preferentially reacted with 70/75 kD microfilarial antigens. A proportion of such sera inhibited the binding of monoclonal antibody MF1 to its target epitope; eight of nine inhibitory sera were from patients with active infections, evidenced by the presence of microfilariae or filarial antigens in the donors' blood, but who were amicrofilaraemic. These results indicate that some amicrofilaraemic residents of areas where brugian filariasis is endemic develop immune reactions to a microfilarial stage-specific antigen that was previously identified as a potentially 'protective' parasite antigen in animal models of lymphatic filariasis.
PubMed: 2320381
Affiliations:
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Purtoma</name></author><author><name sortKey="Piessens, W F" sort="Piessens, W F" uniqKey="Piessens W" first="W F" last="Piessens">W F Piessens</name></author></analytic><series><title level="j">Parasite immunology</title><idno type="ISSN">0141-9838</idno><imprint><date when="1990" type="published">1990</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Animals</term><term>Antibodies, Helminth (analysis)</term><term>Antibodies, Helminth (immunology)</term><term>Antibodies, Monoclonal (immunology)</term><term>Antigens, Helminth (analysis)</term><term>Antigens, Helminth (immunology)</term><term>Binding, Competitive</term><term>Blotting, Western</term><term>Brugia (immunology)</term><term>Elephantiasis, Filarial (epidemiology)</term><term>Elephantiasis, Filarial (immunology)</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Female</term><term>Filariasis (immunology)</term><term>Humans</term><term>Immunoblotting</term><term>Immunoglobulin G (analysis)</term><term>Immunoglobulin G (immunology)</term><term>Immunoglobulin M (analysis)</term><term>Immunoglobulin M (immunology)</term><term>Indonesia</term><term>Male</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Animaux</term><term>Anticorps antihelminthe (analyse)</term><term>Anticorps antihelminthe (immunologie)</term><term>Anticorps monoclonaux (immunologie)</term><term>Antigènes d'helminthe (analyse)</term><term>Antigènes d'helminthe (immunologie)</term><term>Brugia (immunologie)</term><term>Femelle</term><term>Filariose lymphatique (immunologie)</term><term>Filariose lymphatique (épidémiologie)</term><term>Filarioses (immunologie)</term><term>Fixation compétitive</term><term>Humains</term><term>Immunoglobuline G (analyse)</term><term>Immunoglobuline G (immunologie)</term><term>Immunoglobuline M (analyse)</term><term>Immunoglobuline M (immunologie)</term><term>Immunotransfert</term><term>Indonésie</term><term>Mâle</term><term>Technique de Western</term><term>Test ELISA</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antibodies, Helminth</term><term>Antigens, Helminth</term><term>Immunoglobulin G</term><term>Immunoglobulin M</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Helminth</term><term>Antibodies, Monoclonal</term><term>Antigens, Helminth</term><term>Immunoglobulin G</term><term>Immunoglobulin M</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Indonesia</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Anticorps antihelminthe</term><term>Antigènes d'helminthe</term><term>Immunoglobuline G</term><term>Immunoglobuline M</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antihelminthe</term><term>Anticorps monoclonaux</term><term>Antigènes d'helminthe</term><term>Brugia</term><term>Filariose lymphatique</term><term>Filarioses</term><term>Immunoglobuline G</term><term>Immunoglobuline M</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia</term><term>Elephantiasis, Filarial</term><term>Filariasis</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Animals</term><term>Binding, Competitive</term><term>Blotting, Western</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Female</term><term>Humans</term><term>Immunoblotting</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Animaux</term><term>Femelle</term><term>Fixation compétitive</term><term>Humains</term><term>Immunotransfert</term><term>Indonésie</term><term>Mâle</term><term>Technique de Western</term><term>Test ELISA</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Indonésie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Studies in animal models indicate that antibodies to surface antigens of microfilariae participate in the control of parasitaemia resulting from infections with lymphatic filarial nematodes. In an attempt to identify parasite antigens that elicit such 'protective' host responses, we compared the antigen recognition patterns of persons who remained amicrofilaraemic after 3-6 years of exposure to Brugia malayi with those of individuals who developed patent filariasis during the same period. IgG antibodies in sera from immigrants identified between 0 and 25 microfilarial antigens on Western blots. The highest degree of reactivity was observed with antigens in the 65-75 kD and 20-30 kD ranges, and with a group of high mol. wt antigens (greater than 180 kD). Sera from amicrofilaraemic donors preferentially reacted with 70/75 kD microfilarial antigens. A proportion of such sera inhibited the binding of monoclonal antibody MF1 to its target epitope; eight of nine inhibitory sera were from patients with active infections, evidenced by the presence of microfilariae or filarial antigens in the donors' blood, but who were amicrofilaraemic. These results indicate that some amicrofilaraemic residents of areas where brugian filariasis is endemic develop immune reactions to a microfilarial stage-specific antigen that was previously identified as a potentially 'protective' parasite antigen in animal models of lymphatic filariasis.</div></front></TEI><affiliations><list><country><li>Indonésie</li></country></list><tree><noCountry><name sortKey="Basundari, E" sort="Basundari, E" uniqKey="Basundari E" first="E" last="Basundari">E. Basundari</name><name sortKey="Fuhrman, J A" sort="Fuhrman, J A" uniqKey="Fuhrman J" first="J A" last="Fuhrman">J A Fuhrman</name><name sortKey="Piessens, W F" sort="Piessens, W F" uniqKey="Piessens W" first="W F" last="Piessens">W F Piessens</name><name sortKey="Purtoma, H" sort="Purtoma, H" uniqKey="Purtoma H" first="H" last="Purtoma">H. Purtoma</name><name sortKey="Turner, H" sort="Turner, H" uniqKey="Turner H" first="H" last="Turner">H. Turner</name></noCountry><country name="Indonésie"><noRegion><name sortKey="Kurniawan, L" sort="Kurniawan, L" uniqKey="Kurniawan L" first="L" last="Kurniawan">L. Kurniawan</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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